![]() ![]() A button to quickly select a full linear insert in the 'Build a Construct' window 'Anchor' and 'Core' domains of Primers are now recognized as Features in Sequence Windows A shortcut (S) to quickly show or mask Features (in the Features tab of Sequence Windows) A toggle button to highlight differences in aligned proteins Display Features in Protein Align (Local Align) Inherit Features when copying/Pasting Protein sequences Non formatted copy of Protein sequence (Copy More… Menu) A rapid switch between a DNA and Protein Align window Inherit Features when reverse-translating a DNA sequence Scan for peptide Features in Protein Sequences A button/menu to choose particular sites to be displayed in Restriction maps. An option in the Restriction Map window to only translate nucleotides that are in uppercase An option in the Preferences to use the Codon code from Codon Usage tables as a Genetic code used for translation An option in the Preferences to select pK value tables to use for pI estimation MacOSX version now distributed as a signed application (Mountain Lion Gatekeeper compatibility) Estimates Isoelectric point of protein sequences (DNA and Protein Sequence Window) Insertion point position when editing a protein sequence Error in definition of PreScission site Slow down under certain Windows install due to autosaving Bug in "show info" toggle under Windows and Linux Detection of overlapping Primers in PCR a preference to limit or not the width of Seq & Prot windows (see the available contextual help window to get more details on new functions) Serial Cloner is still distributed as a freeware although you are welcome to support it making a donation (see the link on the web site or the About. You will see underneath a more complete list of Additions/Corrections present in Serial Cloner 2.6 and 2.6.1. I tried to solve this problem in v2.6.1 considering that the autosave routine was the cause. Although I could not reproduce this problems with my version of Windows, a few people reported. Some people faced also a very sluggish behavior of Serial Cloner under windows. More problematic, the button “Show information” was not working properly anymore under windows (and Linux). While improving detection of PCR primers overlap, I messed up the detection when PCR was taking place over the origin of the plasmid. Getting Started with MacVector: An overview of primer design workflows in MacVector.This is a quick update mostly to correct bugs I introduced in version 2.6.Melissa Caimano on HOW DO I video guides to common molecular biology workflows.admin on HOW DO I video guides to common molecular biology workflows.mariam abdelmalak on Major release details – Summary.Brian on Designing primers and documenting In-Fusion Cloning with MacVector. ![]() Chris on Designing primers and documenting In-Fusion Cloning with MacVector.How to call heterozygotes in trace files or Assembly Projects.MacVectorTip: How to Customize the Toolbars of MacVector windows.MacVectorTip: Selecting the sequence from a single restriction enzyme site to the end of a linear sequence.Sequence Assembly: What can Assembler do for my lab?.MacVector will directly import many file formats such as common sequence formats such as Genbank, FASTA, FASTQ plus from software packages such as Sequencher Projects and Serial Cloner, For example you may prefer features to be displayed on just those two levels instead of being distributed over the multiple levels as per the default settings. However, MacVector’s graphics are highly customizable and you can adjust the graphical settings to display the plasmid exactly as you want. This sequence was opened using the MacVector defaults. It’s been opened directly in MacVector by double clicking the file. Here’s a plasmid sequence downloaded from the Addgene website in Snapgene format. However, Snapgene will always place features on the same two levels and so features sometimes overlap. For example MacVector has multiple levels (up to six) outside and inside a plasmid and will always try to place features so that no feature overlaps another. However, there are some aspects to the display that are not the same between the two applications. The colors of features will be the same as the original. When you import a Snapgene file the appearance will be very similar. This is very useful when downloading plasmid sequences from the wonderful Addgene plasmid repository. You just need to use FILE | OPEN or double click the file. MacVector will directly import SnapGene DNA files. ![]()
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